Literature DB >> 15062121

Signal transduction: implications for Ras-dependent ERK signaling.

Stéphane Ory1, Deborah K Morrison.   

Abstract

Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.

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Year:  2004        PMID： 15062121     DOI： 10.1016/j.cub.2004.03.023

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  20 in total

1.  IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds.

Authors:  Chiyuan Chen; Robert E Lewis; Michael A White
Journal:  J Biol Chem       Date:  2008-03-10       Impact factor: 5.157

2.  Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo.

Authors:  Swathi Arur; Tim Schedl
Journal:  Nat Protoc       Date:  2014-01-23       Impact factor: 13.491

3.  Kinase regulation by hydrophobic spine assembly in cancer.

Authors:  Jiancheng Hu; Lalima G Ahuja; Hiruy S Meharena; Natarajan Kannan; Alexandr P Kornev; Susan S Taylor; Andrey S Shaw
Journal:  Mol Cell Biol       Date:  2014-10-27       Impact factor: 4.272

4.  Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region.

Authors:  X Wang; T-T Wang; J H White; G P Studzinski
Journal:  Oncogene       Date:  2006-05-29       Impact factor: 9.867

Review 5.  Myogenic regulatory factors: The orchestrators of myogenesis after 30 years of discovery.

Authors:  Hasan A Asfour; Mohammed Z Allouh; Raed S Said
Journal:  Exp Biol Med (Maywood)       Date:  2018-01-07

6.  A sphingolipid elicitor-inducible mitogen-activated protein kinase is regulated by the small GTPase OsRac1 and heterotrimeric G-protein in rice 1[w].

Authors:  Damien Lieberherr; Nguyen Phuong Thao; Ayako Nakashima; Kenji Umemura; Tsutomu Kawasaki; Ko Shimamoto
Journal:  Plant Physiol       Date:  2005-06-10       Impact factor: 8.340

7.  Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes.

Authors:  Priyangi M Perera; Ewa Wypasek; Shashi Madhavan; Birgit Rath-Deschner; Jie Liu; Jin Nam; Bjoern Rath; Yan Huang; James Deschner; Nicholas Piesco; Chuanyue Wu; Sudha Agarwal
Journal:  Arthritis Res Ther       Date:  2010-05-28       Impact factor: 5.156

8.  p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.

Authors:  Jan Czyzyk; Hui-Chen Chen; Kim Bottomly; Richard A Flavell
Journal:  J Biol Chem       Date:  2008-06-24       Impact factor: 5.157

9.  Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation.

Authors:  Xuening Wang; Tian-Tian Wang; John H White; George P Studzinski
Journal:  Exp Cell Res       Date:  2007-05-31       Impact factor: 3.905

10.  hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells.

Authors:  Xuening Wang; Rahul Patel; George P Studzinski
Journal:  Mol Cancer Ther       Date:  2008-09       Impact factor: 6.261
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