Literature DB >> 15061724

Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp.).

Carlos A Málaga1, Richard E Weller, J Roger Broderson, Alfonso S Gozalo.   

Abstract

An apparently normal, non-tuberculin-reacting, splenectomized owl monkey presented tuberculosis-like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid-fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.

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Year:  2004        PMID: 15061724     DOI: 10.1111/j.1600-0684.2004.00060.x

Source DB:  PubMed          Journal:  J Med Primatol        ISSN: 0047-2565            Impact factor:   0.667


  1 in total

1.  Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.

Authors:  David R Cavanagh; Clemens H M Kocken; John H White; Graeme J M Cowan; Kay Samuel; Martin A Dubbeld; Annemarie Voorberg-van der Wel; Alan W Thomas; Jana S McBride; David E Arnot
Journal:  PLoS One       Date:  2014-01-08       Impact factor: 3.240

  1 in total

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