| Literature DB >> 15061198 |
Naohi Sahara1, Akihiro Takeshita.
Abstract
Multiple myeloma (MM) is characterized by increased numbers of malignant plasma cells. Plasma cells, that represent the terminal differentiation of B lymphocytes, have considerable heterogeneity of surface markers expressed on them. Some studies showed the prognostic significance of several immunophenotypic molecules on MM cells. Here, we review several surface markers related to their prognostic significance in MM patients. We also report that CD56-negative MM is the unique entity characterized by poor prognosis with high incidence of extramedullary disease, Bence Jones protein, renal insufficiency, thrombocytopenia and plasmablastic morphology.Entities:
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Year: 2004 PMID： 15061198 DOI： 10.1080/1042819031000149377
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022