Literature DB >> 15060053

Protein-protein interactions of proteins from the ESAT-6 family of Mycobacterium tuberculosis.

Limei Meng Okkels1, Peter Andersen.   

Abstract

In the present study, we demonstrate that, in analogy with the genes encoding ESAT-6 and CFP-10, the genes rv0287 and rv0288 from the ESAT-6 gene family are cotranscribed. Using Western-Western blotting and protein-print overlay methodologies, we demonstrate that ESAT-6 and CFP-10, as well as the protein pair Rv0288/Rv0287, interact pairwise in a highly specific way. Most notably, the ESAT-6 proteins interact directly with Rv3873, a possible cell envelope component of the ESAT-6 secretion pathway.

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Year:  2004        PMID： 15060053      PMCID： PMC412125          DOI： 10.1128/JB.186.8.2487-2491.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


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