Literature DB >> 1505976

D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21.

A C Warren1, M B Petersen, W Van Hul, M G McInnis, C Van Broeckhoven, T K Cox, A Chakravarti, S E Antonarakis.   

Abstract

A plasmid, AWZ1, that contained a dinucleotide (GT)n repeat was identified from a chromosome 21-specific genomic library. When amplified by PCR from human genomic DNA, the repeat length was highly polymorphic between individuals; its location, D21S215, was mapped in the CEPH pedigrees by linkage analysis to the pericentromeric region of chromosome 21. It is the closest polymorphic marker to alphoid sequences on this chromosome.

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Year:  1992        PMID： 1505976     DOI： 10.1016/0888-7543(92)90072-z

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  7 in total

1.  DNA polymorphism analysis in families with recurrence of free trisomy 21.

Authors:  C G Pangalos; C C Talbot; J G Lewis; P A Adelsberger; M B Petersen; J L Serre; M O Rethoré; M C de Blois; P Parent; A A Schinzel
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

2.  Double non-disjunction in maternal meiosis II giving rise to a fetus with 48,XXX,+21.

Authors:  V M Park; R R Bravo; L P Shulman
Journal:  J Med Genet       Date:  1995-08       Impact factor: 6.318

3.  Unusual genotypes in the COL6A1 gene in parents of children with trisomy 21 and major congenital heart defects.

Authors:  G E Davies; C M Howard; M J Farrer; M M Coleman; L M Cullen; R Williamson; R K Wyse; A M Kessling
Journal:  Hum Genet       Date:  1994-04       Impact factor: 4.132

4.  Meiotic crossing-over in nondisjoined chromosomes of children with trisomy 21 and a congenital heart defect.

Authors:  C M Howard; G E Davies; M J Farrer; L M Cullen; M M Coleman; R Williamson; R K Wyse; R Palmer; A M Kessling
Journal:  Am J Hum Genet       Date:  1993-08       Impact factor: 11.025

5.  Isolation of a cosmid clone corresponding to an inv(21) breakpoint of a patient with transient abnormal myelopoiesis.

Authors:  T Ohta; M Nakano; T Tsujita; K Abe; K Osoegawa; T Yamagata; K Yoshiura; Y Jinno; E Soeda; Y Nakamura; N Niikawa
Journal:  Am J Hum Genet       Date:  1996-03       Impact factor: 11.025

6.  Cytogenetic, FISH and DNA studies in 11 individuals from a family with two siblings with dup(21q) Down syndrome.

Authors:  O Bartsch; U König; M B Petersen; H Poulsen; M Mikkelsen; F Palau; F Prieto; E Schwinger
Journal:  Hum Genet       Date:  1993-09       Impact factor: 4.132

7.  Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.

Authors:  K Kamino; H T Orr; H Payami; E M Wijsman; M E Alonso; S M Pulst; L Anderson; S O'dahl; E Nemens; J A White
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025
  7 in total

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