| Literature DB >> 15059616 |
V Anne Morrison1, Suna Onengut-Gumuscu, Patrick Concannon.
Abstract
A collection of 767 multiplex type 1 diabetes families from the US and UK were tested for linkage to the IRS1 gene and for allelic association with a specific variant of IRS1, G972R. Pedigree disequilibrium testing revealed preferential transmission of the 972R allele to affected offspring in these families (P = 0.02). Linkage analyses conditioning on status at IRS1 position 972 suggest the possibility of interaction with an unidentified locus on chromosome 8.Entities:
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Year: 2004 PMID： 15059616 DOI： 10.1016/j.ymgme.2003.10.018
Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797