| Literature DB >> 15059240 |
A S Hill1, J A Werner, Q R Rogers, S L O'Neill, M M Christopher.
Abstract
The antioxidant lipoic acid (LA) is administered to humans and pets. We described acute toxicity and maximum tolerated dose (MTD) of LA in cats. In progression, 10 healthy adult male cats received orally 60 (high), 30 (low), or 0 mg LA/kg (control). Serum enzyme activities and concentrations of bile acids, ammonia, amino acids (AA), LA and dihydrolipoic acid (DHLA) were measured, and tissues examined microscopically. Significant clinical toxicity with changes in ammonia and AA concentrations occurred in all high-dose cats. Oral LA produced hepatocellular toxicity and MTD was < 30 mg/kg in cats.Entities:
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Year: 2004 PMID： 15059240 DOI： 10.1111/j.1439-0396.2003.00472.x
Source DB: PubMed Journal: J Anim Physiol Anim Nutr (Berl) ISSN： 0931-2439 Impact factor: 2.130