Effect of carbon and nitrogen sources on the production of penitrem B by Penicillium aurantiogriseum.

Effect of different carbon and nitrogen sources on the production of penitrem B was studied. D-Xylose induced maximum penitrem B production, while melibiose, glycerol, citric acid and succinic acid were poor substrates. Potassium nitrate, L-asparagine, sodium nitrate, glycine, DL-aspartic acid and L-tryptophan supported good production of penitrem B. Conversely zirconyl nitrate, barium nitrate, aluminum nitrate, acetanilide, 4-aminobenzoic acid, 4-nitrobenzoic acid and 4-nitroaniline were toxic and did not even permit the growth of the fungus.