OBJECTIVE: To evaluate the antidepressant activity of total triterpenes from Centella asiatica in forced swimming test. METHODS: Mice were randomly divided into control group, model group and treatment group. The effect of total triterpenes from Centella asiatica on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed. RESULTS: Imipramine and total triterpenes from Centella asiatica reduced the immobility time and ameliorated the imbalance of amino acid levels. CONCLUSION: The total triterpenes from Centella asiatica had antidepressant activity.
OBJECTIVE: To evaluate the antidepressant activity of total triterpenes from Centella asiatica in forced swimming test. METHODS:Mice were randomly divided into control group, model group and treatment group. The effect of total triterpenes from Centella asiatica on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed. RESULTS:Imipramine and total triterpenes from Centella asiatica reduced the immobility time and ameliorated the imbalance of amino acid levels. CONCLUSION: The total triterpenes from Centella asiatica had antidepressant activity.