| Literature DB >> 1505735 |
M Sasatsu1, Y Shibata, N Noguchi, M Kono.
Abstract
A gene encoding high-level resistance to ethidium bromide (EB) and antiseptics was isolated from a transferable plasmid, pTZ22, in Staphylococcus aureus. DNA sequencing revealed that the plasmid has two copies of the ebr gene that normally mediates low-level resistance to EB and antiseptics. The efflux rate for EB of strains with duplicated ebr genes was twice the rate of strains with a single ebr gene. It was concluded that the duplication of ebr is responsible for the high-level resistance to EB and antiseptics.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1505735 DOI： 10.1016/0378-1097(92)90514-o
Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742