Literature DB >> 15056850

Mutagenicities of 8-hydroxyguanine and 2-hydroxyadenine produced by reactive oxygen species.

Hiroyuki Kamiya1.   

Abstract

Oligodeoxyribonucleotides containing 8-hydroxyguanine and 2-hydroxyadenine, purine lesions produced in cells by reactive oxygen species, were synthesized and inserted into vector DNAs to introduce each lesion at a predetermined site. The manipulated DNAs were transfected into living cells, and the mutants induced by each DNA lesion were collected and analyzed. In addition, the mutations induced by damaged DNA precursors with the two oxidized purine bases were studied by the use of chemically synthesized nucleoside triphosphates. In this review article, the author summarizes the mutagenic potentials of the two oxidized purine bases, by focusing on experiments examined by the author and his collaborators.

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Year:  2004        PMID： 15056850     DOI： 10.1248/bpb.27.475

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  8 in total

1.  Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η.

Authors:  Amritraj Patra; Leslie D Nagy; Qianqian Zhang; Yan Su; Livia Müller; F Peter Guengerich; Martin Egli
Journal:  J Biol Chem       Date:  2014-04-23       Impact factor: 5.157

2.  Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2.

Authors:  Alessandra Amoroso; Lorenzo Concia; Caterina Maggio; Cécile Raynaud; Catherine Bergounioux; Emmanuele Crespan; Rino Cella; Giovanni Maga
Journal:  Plant Cell       Date:  2011-02-15       Impact factor: 11.277

3.  Saturated hydrogen saline protects rats from acute lung injury induced by paraquat.

Authors:  Hui-Li Zhang; Yuan-Fei Liu; Xu-Rui Luo; Wei-Hua Tan; Liang Huang
Journal:  World J Emerg Med       Date:  2011

4.  Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine.

Authors:  Masaki Hori; Shin-Ichiro Yonekura; Takehiko Nohmi; Petr Gruz; Hiroshi Sugiyama; Shuji Yonei; Qiu-Mei Zhang-Akiyama
Journal:  J Nucleic Acids       Date:  2010-09-26

5.  Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol λ-knockdown cells.

Authors:  Hiroyuki Kamiya; Masahiro Kurokawa; Tetsuaki Makino; Miwako Kobayashi; Ichiro Matsuoka
Journal:  Genes Environ       Date:  2015-08-01

6.  Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension.

Authors:  Qian Zhang; Xuemei Gao; Xuehui Chen; Yanlong Chen; Mengqi Feng; Xin Huang; Changtao Li; Fang Han
Journal:  Nat Sci Sleep       Date:  2022-04-08

7.  Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts.

Authors:  Emmanuele Crespan; Ulrich Hübscher; Giovanni Maga
Journal:  Nucleic Acids Res       Date:  2007-07-30       Impact factor: 16.971

8.  8-oxoguanine causes spontaneous de novo germline mutations in mice.

Authors:  Mizuki Ohno; Kunihiko Sakumi; Ryutaro Fukumura; Masato Furuichi; Yuki Iwasaki; Masaaki Hokama; Toshimichi Ikemura; Teruhisa Tsuzuki; Yoichi Gondo; Yusaku Nakabeppu
Journal:  Sci Rep       Date:  2014-04-15       Impact factor: 4.379
  8 in total

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