Literature DB >> 1505667

Flow-induced prostacyclin production is mediated by a pertussis toxin-sensitive G protein.

F Berthiaume1, J A Frangos.   

Abstract

Fluid flow and several other agonists induce prostacyclin (PGI2) production in endothelial cells. G proteins mediate the response of a large number of hormones such as histamine, but the transduction pathway of the flow signal is unclear. We found that GDP beta S and pertussis toxin inhibited flow-induced prostacyclin production in human umbilical vein endothelial cells. In addition, flow potentiated the histamine-induced production of PGI2. This suggests that flow stimulates prostacyclin production via a pertussis toxin-sensitive G protein and modulates the stimulus-response coupling of other agonists.

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Keywords:  Non-programmatic

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Year:  1992        PMID： 1505667     DOI： 10.1016/0014-5793(92)81292-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

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2.  Assessment of vascular autonomic function using peripheral arterial tonometry.

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Journal:  Heart Vessels       Date:  2016-07-11       Impact factor: 2.037

Review 3.  Flow-mediated endothelial mechanotransduction.

Authors:  P F Davies
Journal:  Physiol Rev       Date:  1995-07       Impact factor: 37.312

4.  Pulsatile shear stress leads to DNA fragmentation in human SH-SY5Y neuroblastoma cell line.

Authors:  D H Triyoso; T A Good
Journal:  J Physiol       Date:  1999-03-01       Impact factor: 5.182

5.  A mechanical strain-induced 1-aminocyclopropane-1-carboxylic acid synthase gene.

Authors:  J R Botella; R N Arteca; J A Frangos
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

Review 6.  The shear stress of it all: the cell membrane and mechanochemical transduction.

Authors:  Charles R White; John A Frangos
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2007-08-29       Impact factor: 6.237

7.  Rapid changes in shear stress induce dissociation of a G alpha(q/11)-platelet endothelial cell adhesion molecule-1 complex.

Authors:  Laura A Otte; Kelly S Bell; Laurent Loufrani; Jiunn-Chern Yeh; Benoît Melchior; Diep N Dao; Hazel Y Stevens; Charles R White; John A Frangos
Journal:  J Physiol       Date:  2009-03-30       Impact factor: 5.182

Review 8.  Impact of pulmonary vascular resistances in heart transplantation for congenital heart disease.

Authors:  Avihu Z Gazit; Charles E Canter
Journal:  Curr Cardiol Rev       Date:  2011-05

9.  The importance of velocity acceleration to flow-mediated dilation.

Authors:  Lee Stoner; Joanna M Young; Simon Fryer; Manning J Sabatier
Journal:  Int J Vasc Med       Date:  2012-01-19
  9 in total

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