Chris Bushe1, Richard Holt. 1. Eli Lilly & Co. Ltd, Basingstoke, University of Southampton, UK. bushe_chris@lilly.com
Abstract
BACKGROUND: A number of studies have examined the prevalence of diabetes mellitus and impaired glucose tolerance in general populations and in those with schizophrenia and other forms of serious mental illness. AIMS: To establish whether it is possible to describe accurately comparative rates of diabetes mellitus and impaired glucose tolerance in populations of people with schizophrenia and those without mental illness. METHOD: Review of current literature. RESULTS: Research published in the pre-neuroleptic era suggested that people with severe mental illness were at increased risk of developing glycaemic abnormalities. Recent studies appear to confirm that the prevalence of diabetes and impaired glucose tolerance may be higher in people with schizophrenia than in the general population, and suggest that patients with schizophrenia have impaired glucose tolerance even before they begin treatment. CONCLUSIONS: Schizophrenia may be a significant and independent risk factor for both diabetes and impaired glucose tolerance. Current data preclude precise estimates of the prevalence of these conditions among people with schizophrenia.
BACKGROUND: A number of studies have examined the prevalence of diabetes mellitus and impaired glucose tolerance in general populations and in those with schizophrenia and other forms of serious mental illness. AIMS: To establish whether it is possible to describe accurately comparative rates of diabetes mellitus and impaired glucose tolerance in populations of people with schizophrenia and those without mental illness. METHOD: Review of current literature. RESULTS: Research published in the pre-neuroleptic era suggested that people with severe mental illness were at increased risk of developing glycaemic abnormalities. Recent studies appear to confirm that the prevalence of diabetes and impaired glucose tolerance may be higher in people with schizophrenia than in the general population, and suggest that patients with schizophrenia have impaired glucose tolerance even before they begin treatment. CONCLUSIONS:Schizophrenia may be a significant and independent risk factor for both diabetes and impaired glucose tolerance. Current data preclude precise estimates of the prevalence of these conditions among people with schizophrenia.
Authors: Hugh C Hendrie; Donald Lindgren; Donald P Hay; Kathleen A Lane; Sujuan Gao; Christianna Purnell; Stephanie Munger; Faye Smith; Jeanne Dickens; Malaz A Boustani; Christopher M Callahan Journal: Am J Geriatr Psychiatry Date: 2013-02-06 Impact factor: 4.105
Authors: Ruth S Shim; Benjamin G Druss; Shun Zhang; Giyeon Kim; Adesoji Oderinde; Sosunmolu Shoyinka; George Rust Journal: Schizophr Res Date: 2013-12-28 Impact factor: 4.939
Authors: Jaya L Padmanabhan; Pranav Nanda; Neeraj Tandon; Suraj S Mothi; Nicolas Bolo; Steven McCarroll; Brett A Clementz; Elliot S Gershon; Godfrey D Pearlson; John A Sweeney; Carol A Tamminga; Matcheri S Keshavan Journal: J Psychiatr Res Date: 2016-02-23 Impact factor: 4.791