OBJECTIVE: This study characterized cognitive functioning in elderly patients with bipolar disorder. METHOD: The cognitive functioning of 18 euthymic patients with a history of bipolar disorder I or II, ages 60 years and older, was tested with the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale, and the Executive Interview. Cognitive functioning in these subjects was compared with that of an age- and education-matched group of 45 comparison subjects without mood disorders. RESULTS: Approximately half of the bipolar subjects scored one or more standard deviations below the mean of the comparison subjects on the MMSE (N=8, 44%) and the Mattis Dementia Rating Scale total (N=10, 56%). On the Executive Interview, three subjects (17%) scored between one and two standard deviations below the mean of the comparison subjects. CONCLUSIONS: A significant proportion of older bipolar subjects exhibited neuropsychological deficits when they were clinically euthymic.
OBJECTIVE: This study characterized cognitive functioning in elderly patients with bipolar disorder. METHOD: The cognitive functioning of 18 euthymic patients with a history of bipolar disorder I or II, ages 60 years and older, was tested with the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale, and the Executive Interview. Cognitive functioning in these subjects was compared with that of an age- and education-matched group of 45 comparison subjects without mood disorders. RESULTS: Approximately half of the bipolar subjects scored one or more standard deviations below the mean of the comparison subjects on the MMSE (N=8, 44%) and the Mattis Dementia Rating Scale total (N=10, 56%). On the Executive Interview, three subjects (17%) scored between one and two standard deviations below the mean of the comparison subjects. CONCLUSIONS: A significant proportion of older bipolar subjects exhibited neuropsychological deficits when they were clinically euthymic.
Authors: Colin A Depp; David J Moore; David Sitzer; Barton W Palmer; Lisa T Eyler; Scott Roesch; Barry D Lebowitz; Dilip V Jeste Journal: J Affect Disord Date: 2007-01-16 Impact factor: 4.839
Authors: Colin A Depp; Ashley E Cain; Barton W Palmer; David J Moore; Lisa T Eyler; Barry D Lebowitz; Thomas L Patterson; Dilip V Jeste Journal: J Clin Psychopharmacol Date: 2008-04 Impact factor: 3.153
Authors: Ariel G Gildengers; Benoit H Mulsant; Amy Begley; Sati Mazumdar; Adriana V Hyams; Charles F Reynolds Iii; David J Kupfer; Meryl A Butters Journal: Bipolar Disord Date: 2009-08-28 Impact factor: 6.744
Authors: Brent P Forester; Chris C Streeter; Yosef A Berlow; Hua Tian; Megan Wardrop; Chelsea T Finn; David Harper; Perry F Renshaw; Constance M Moore Journal: Am J Geriatr Psychiatry Date: 2009-01 Impact factor: 4.105