S Hiramatsu1, Y Tajiri, T Karashima. 1. Department of Metabolism and Endocrinology, Department of Clinical Research, National Kyushu Medical Centre, Fukuoka, Japan. hiramatsu@med.hosp.go.jp
Abstract
AIM: To investigate clinical efficacy of pioglitazone in association with plasma adiponectin concentration in type 2 diabetic patients. METHODS: Ten diabetic patients were treated with 15 or 30 mg of pioglitazone for 8 weeks, and association between plasma adiponectin concentration before treatment and decrease in glycated albumin levels was examined. RESULTS: Treatment with pioglitazone for 8 weeks lowered glycated albumin level (27.1 +/- 1.2 to 23.8 +/- 1.4%, p < 0.05), and inverse relationship between changes in glycated albumin and plasma adiponectin concentration before treatment was revealed (r = -0.66, p < 0.05). Plasma adiponectin concentrations of patients whose glycated albumin level reduced by more than 10% of the levels before treatment were significantly lower than those of patients whose glycaemic control was affected less (5.2 +/- 0.6 vs. 8.0 +/- 1.0 micro g/ml, p < 0.05). CONCLUSION: Lower plasma adiponectin concentration predicts the clinical efficacy of pioglitazone.
AIM: To investigate clinical efficacy of pioglitazone in association with plasma adiponectin concentration in type 2 diabeticpatients. METHODS: Ten diabeticpatients were treated with 15 or 30 mg of pioglitazone for 8 weeks, and association between plasma adiponectin concentration before treatment and decrease in glycated albumin levels was examined. RESULTS: Treatment with pioglitazone for 8 weeks lowered glycated albumin level (27.1 +/- 1.2 to 23.8 +/- 1.4%, p < 0.05), and inverse relationship between changes in glycated albumin and plasma adiponectin concentration before treatment was revealed (r = -0.66, p < 0.05). Plasma adiponectin concentrations of patients whose glycated albumin level reduced by more than 10% of the levels before treatment were significantly lower than those of patients whose glycaemic control was affected less (5.2 +/- 0.6 vs. 8.0 +/- 1.0 micro g/ml, p < 0.05). CONCLUSION: Lower plasma adiponectin concentration predicts the clinical efficacy of pioglitazone.
Authors: David K Simon; Tanya Simuni; Jordan Elm; Joanne Clark-Matott; Allison K Graebner; Liana Baker; Susan R Dunlop; Marina Emborg; Cornelia Kamp; John C Morgan; G Webster Ross; Saloni Sharma; Bernard Ravina Journal: J Parkinsons Dis Date: 2015 Impact factor: 5.568