Literature DB >> 15055985

Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?

Ian M Bell1.   

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Year:  2004        PMID： 15055985     DOI： 10.1021/jm0305467

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  16 in total

1.  Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.

Authors:  Richard T Eastman; John White; Oliver Hucke; Kohei Yokoyama; Christophe L M J Verlinde; Michael A Hast; Lorena S Beese; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Journal:  Mol Biochem Parasitol       Date:  2006-12-22       Impact factor: 1.759

Review 2.  Peptidomimetics in cancer chemotherapy.

Authors:  C Avendaño; J C Menéndez
Journal:  Clin Transl Oncol       Date:  2007-09       Impact factor: 3.405

3.  Computational studies of the farnesyltransferase ternary complex part I: substrate binding.

Authors:  Guanglei Cui; Bing Wang; Kenneth M Merz
Journal:  Biochemistry       Date:  2005-12-20       Impact factor: 3.162

4.  Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.

Authors:  Amanda J DeGraw; Michael J Keiser; Joshua D Ochocki; Brian K Shoichet; Mark D Distefano
Journal:  J Med Chem       Date:  2010-03-25       Impact factor: 7.446

5.  Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.

Authors:  Brian S Henriksen; Jessica L Anderson; Christine A Hrycyna; Richard A Gibbs
Journal:  Bioorg Med Chem Lett       Date:  2005-09-23       Impact factor: 2.823

Review 6.  Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics.

Authors:  Jeremy L Yap; Shilpa Worlikar; Alexander D MacKerell; Paul Shapiro; Steven Fletcher
Journal:  ChemMedChem       Date:  2011-01-03       Impact factor: 3.466

7.  Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.

Authors:  Steven Fletcher; Christopher G Cummings; Kasey Rivas; William P Katt; Carrie Hornéy; Frederick S Buckner; Debopam Chakrabarti; Saïd M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Journal:  J Med Chem       Date:  2008-08-08       Impact factor: 7.446

8.  Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.

Authors:  Pravin Bendale; Srinivas Olepu; Praveen Kumar Suryadevara; Vivek Bulbule; Kasey Rivas; Laxman Nallan; Brian Smart; Kohei Yokoyama; Sudha Ankala; Prakash Rao Pendyala; David Floyd; Louis J Lombardo; David K Williams; Frederick S Buckner; Debopam Chakrabarti; Christophe L M J Verlinde; Wesley C Van Voorhis; Michael H Gelb
Journal:  J Med Chem       Date:  2007-08-28       Impact factor: 7.446

9.  Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines.

Authors:  Lawrence P Tardibono; Marvin J Miller
Journal:  Org Lett       Date:  2009-04-02       Impact factor: 6.005

10.  Caged protein prenyltransferase substrates: tools for understanding protein prenylation.

Authors:  Amanda J DeGraw; Michael A Hast; Juhua Xu; Daniel Mullen; Lorena S Beese; George Barany; Mark D Distefano
Journal:  Chem Biol Drug Des       Date:  2008-09       Impact factor: 2.817
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