Left ventricular systolic and diastolic functions in children living in a moderate-severe iodine deficiency area.

Although the effects of impaired thyroid functions on the cardiovascular system is well known, there is no report investigating left ventricular functions in children with iodine deficiency. We evaluated left ventricular functions in children living in a moderate-severe iodine deficient area of northern Turkey. Of 40 children, 13 had stage I, 19 had stage II and eight had stage III goiter. None of the children had clinical signs of hypothyroidism, hyperthyroidism or cardiac dysfunction. Urinary iodine concentration decreased significantly from mild (Group 1) to moderate (Group 2) and severe (Group 3) iodine deficient groups (p <0.05). Mean serum free T3 levels did not differ significantly between the groups. However, a significant difference in mean serum free T4 level was found between Groups 1 and 2 (p <0.05), but remained in the normal range. Although the mean serum TSH level differed significantly between Group 1 and Group 3 and Group 2 and Group 3 (p <0.05), mean values were in the normal range. Mean left ventricular ejection fraction, shortening fraction and diastolic filling parameters did not differ significantly between groups. In conclusion, in case of preserved thyroid hormone levels, a moderate-severe iodine deficiency does not seem to affect left ventricular functions.