Literature DB >> 15053291

How does a normal human cell become a cancer cell?

D D Gan1, M Macaluso, C Cinti, K Khalili, A Giordano.   

Abstract

The mechanism by which cells become cancerous has been studied in several different species and cell types. Here, we will focus on the mechanism by which a normal human cell becomes a cancer cell and specifically discuss genes that researchers have used to transform cells. Studying how those genes affect cellular immortalization and transformation will help researchers understand more about cancer biology, find new treatments for cancer and/or improve cell survival during gene therapy.

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Year:  2003        PMID： 15053291

Source DB:  PubMed          Journal:  J Exp Clin Cancer Res        ISSN： 0392-9078


  6 in total

1.  Cyclin T1 overexpression induces malignant transformation and tumor growth.

Authors:  Cristian Moiola; Paola De Luca; Kevin Gardner; Elba Vazquez; Adriana De Siervi
Journal:  Cell Cycle       Date:  2010-08-01       Impact factor: 4.534

Review 2.  Genetic and epigenetic alterations in breast cancer: what are the perspectives for clinical practice?

Authors:  Alfredo Fucito; Chiara Lucchetti; Antonio Giordano; Gaetano Romano
Journal:  Int J Biochem Cell Biol       Date:  2007-10-23       Impact factor: 5.085

Review 3.  The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development.

Authors:  Gaetano Romano
Journal:  Scientifica (Cairo)       Date:  2013-12-05

4.  An Investigation of the Cytotoxicity and Caspase-Mediated Apoptotic Effect of Green Synthesized Zinc Oxide Nanoparticles Using Eclipta prostrata on Human Liver Carcinoma Cells.

Authors:  Ill-Min Chung; Abdul Abdul Rahuman; Sampath Marimuthu; Arivarasan Vishnu Kirthi; Karunanithi Anbarasan; Govindasamy Rajakumar
Journal:  Nanomaterials (Basel)       Date:  2015-08-12       Impact factor: 5.076

5.  Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.

Authors:  Gaetano Romano
Journal:  ISRN Oncol       Date:  2013-06-06

6.  Development of safer gene delivery systems to minimize the risk of insertional mutagenesis-related malignancies: a critical issue for the field of gene therapy.

Authors:  Gaetano Romano
Journal:  ISRN Oncol       Date:  2012-11-22
  6 in total

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