BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has been more and more often regarded as a serious disorder, because nonalcoholic steatohepatitis (NASH), a part of NAFLD, may progress to the end stage of liver disease. Though an advanced age, obesity, diabetes mellitus (DM) etc. being not infrequent conditions in Korea, are known to exacerbate the severity of this disease, there are only a few Korean reports on this subject. The purpose of this study is to identify possible factors that might add up to the pathological severity of this disorder in Korean patients. METHODS: Of 60 patients with steatosis found at liver biopsy, 43 NAFLD patients were reviewed retrospectively after exclusion of other liver diseases. RESULTS: The cases of steatosis were mild, moderate, and severe in 9. 10, and 24 patients, respectively. The degree of necroinflammatory activity was mild, moderate, and severe in 33, 9, and 1 patients, respectively. There were no established factors directly related to these classes. As to fibrosis, the cases were classified as none, mild, moderate, severe, and cirrhotic in 9, 11, 16, 7, and 0 patients, respectively. The stage of fibrosis correlated with the age (p < 0.001), BMI (body mass index) (p = 0.032), and the platelet count (p = 0.009), but the presence of NASH was associated only with BMI (p = 0.002) and obesity (p = 0.001). CONCLUSION: It seems that there are no factors that are directly related to the degree of steatosis or necroinflammatory activity. BMI seems to be a unique factor directly related to both the severity of fibrosis and the presence of NASH. The age and the platelet count are factors that are directly related to the degree of fibrosis but not to the presence of NASH.
BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) has been more and more often regarded as a serious disorder, because nonalcoholic steatohepatitis (NASH), a part of NAFLD, may progress to the end stage of liver disease. Though an advanced age, obesity, diabetes mellitus (DM) etc. being not infrequent conditions in Korea, are known to exacerbate the severity of this disease, there are only a few Korean reports on this subject. The purpose of this study is to identify possible factors that might add up to the pathological severity of this disorder in Korean patients. METHODS: Of 60 patients with steatosis found at liver biopsy, 43 NAFLD patients were reviewed retrospectively after exclusion of other liver diseases. RESULTS: The cases of steatosis were mild, moderate, and severe in 9. 10, and 24 patients, respectively. The degree of necroinflammatory activity was mild, moderate, and severe in 33, 9, and 1 patients, respectively. There were no established factors directly related to these classes. As to fibrosis, the cases were classified as none, mild, moderate, severe, and cirrhotic in 9, 11, 16, 7, and 0 patients, respectively. The stage of fibrosis correlated with the age (p < 0.001), BMI (body mass index) (p = 0.032), and the platelet count (p = 0.009), but the presence of NASH was associated only with BMI (p = 0.002) and obesity (p = 0.001). CONCLUSION: It seems that there are no factors that are directly related to the degree of steatosis or necroinflammatory activity. BMI seems to be a unique factor directly related to both the severity of fibrosis and the presence of NASH. The age and the platelet count are factors that are directly related to the degree of fibrosis but not to the presence of NASH.
Authors: V Ratziu; P Giral; F Charlotte; E Bruckert; V Thibault; I Theodorou; L Khalil; G Turpin; P Opolon; T Poynard Journal: Gastroenterology Date: 2000-06 Impact factor: 22.682
Authors: T Kawasaki; A Takeshita; K Souda; Y Kobayashi; M Kikuyama; F Suzuki; F Kageyama; Y Sasada; E Shimizu; G Murohisa; S Koide; T Yoshimi; H Nakamura; R Ohno Journal: Am J Gastroenterol Date: 1999-07 Impact factor: 10.864
Authors: J C Luo; S J Hwang; C R Lai; C L Lu; C P Li; S H Tsay; J C Wu; F Y Chang; S D Lee Journal: J Gastroenterol Hepatol Date: 1998-07 Impact factor: 4.029
Authors: James H Tabibian; Mariana Lazo; Francisco A Durazo; Hsin-Chieh Yeh; Myron J Tong; Jeanne M Clark Journal: J Gastroenterol Hepatol Date: 2011-03 Impact factor: 4.029
Authors: Adrian T Billeter; Sarah Wloka; Rouven Behnisch; Thomas Albrecht; Stephanie Roessler; Benjamin Goeppert; Sebastian Mueller; Felix Nickel; Beat Müller Journal: Obes Facts Date: 2021-08-20 Impact factor: 3.942
Authors: Hwa Young Song; Hyo Keun Lee; June Sung Lee; Jong Yeon Kim; Yun Hyuk Yim; Tae Jun Song; Won Ki Bae; Nam-Hoon Kim; Kyung-Ah Kim Journal: Korean J Intern Med Date: 2012-02-28 Impact factor: 2.884