Literature DB >> 15052324

Regulation of arachidonic acid availability for eicosanoid production.

Christina C Leslie1.   

Abstract

Mammalian cells have developed specific pathways for the incorporation, remodeling, and release of arachidonic acid. Acyltransferase and transacylase pathways function to regulate the levels of esterified arachidonic acid in specific phospholipid pools. There are several distinct, differentially regulated phospholipases A2 in cells that mediate agonist-induced release of arachidonic acid. These pathways are important in controlling cellular levels of free arachidonic acid. Both arachidonic acid and its oxygenated metabolites are potent bioactive mediators that regulate a myriad of physiological and pathophysiological processes.

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Year:  2004        PMID： 15052324     DOI： 10.1139/o03-080

Source DB:  PubMed          Journal:  Biochem Cell Biol        ISSN： 0829-8211            Impact factor:   3.626


  36 in total

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Review 2.  Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism.

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Review 3.  New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease.

Authors:  Darla R Shores; David G Binion; Bruce A Freeman; Paul R S Baker
Journal:  Inflamm Bowel Dis       Date:  2010-12-03       Impact factor: 5.325

4.  Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.

Authors:  Sung Ho Moon; Christopher M Jenkins; Xinping Liu; Shaoping Guan; David J Mancuso; Richard W Gross
Journal:  J Biol Chem       Date:  2012-03-02       Impact factor: 5.157

5.  Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells.

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6.  Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function.

Authors:  Christopher M Mulligan; Catherine H Le; Anthony B deMooy; Christopher B Nelson; Adam J Chicco
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7.  Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.

Authors:  Jessica Escoffier; Ikram Jemel; Akemi Tanemoto; Yoshitaka Taketomi; Christine Payre; Christelle Coatrieux; Hiroyasu Sato; Kei Yamamoto; Seiko Masuda; Karin Pernet-Gallay; Virginie Pierre; Shuntaro Hara; Makoto Murakami; Michel De Waard; Gérard Lambeau; Christophe Arnoult
Journal:  J Clin Invest       Date:  2010-04-26       Impact factor: 14.808

8.  Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells.

Authors:  Dawn E Tucker; Allison Stewart; Laxman Nallan; Pravine Bendale; Farideh Ghomashchi; Michael H Gelb; Christina C Leslie
Journal:  J Lipid Res       Date:  2005-08-01       Impact factor: 5.922

9.  2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

Authors:  François Chouinard; Caroline Turcotte; Xiaochun Guan; Marie-Chantal Larose; Samuel Poirier; Line Bouchard; Véronique Provost; Louis Flamand; Nathalie Grandvaux; Nicolas Flamand
Journal:  J Leukoc Biol       Date:  2012-12-12       Impact factor: 4.962

10.  Phospholipid Ozonation Products Activate the 5-Lipoxygenase Pathway in Macrophages.

Authors:  Karin A Zemski Berry; Robert C Murphy
Journal:  Chem Res Toxicol       Date:  2016-08-03       Impact factor: 3.739
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