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Literature DB >> 15052266

Membranes as messengers in T cell adhesion signaling.

Michael L Dustin¹, Trever G Bivona, Mark R Philips.

Abstract

Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery of signals may be crucial, and membrane trafficking from endosomes and the Golgi apparatus seem to be essential in delivering the messages from spatially segregated surface receptors.

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Year: 2004 PMID： 15052266 DOI： 10.1038/ni1057

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

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Cited

88 in total

1. Pattern formation during T-cell adhesion.

Authors: Thomas R Weikl; Reinhard Lipowsky
Journal: Biophys J Date: 2004-09-17 Impact factor: 4.033

Review 2. Central role of paxillin phosphorylation in regulation of LFA-1 integrins activity and lymphocyte migration.

Authors: Larisa Y Romanova; J Frederic Mushinski
Journal: Cell Adh Migr Date: 2011 Nov-Dec Impact factor: 3.405

3. Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses.

Authors: Michael L Dustin
Journal: Self Nonself Date: 2011-04-01

4. Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion.

Authors: Gert Jan Bakker; Christina Eich; Juan A Torreno-Pina; Ruth Diez-Ahedo; Gemma Perez-Samper; Thomas S van Zanten; Carl G Figdor; Alessandra Cambi; Maria F Garcia-Parajo
Journal: Proc Natl Acad Sci U S A Date: 2012-03-12 Impact factor: 11.205

5. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

Authors: Monika Raab; Hongyan Wang; Yuning Lu; Xin Smith; Zhonglin Wu; Klaus Strebhardt; John E Ladbury; Christopher E Rudd
Journal: Immunity Date: 2010-03-25 Impact factor: 31.745

Membranes as messengers in T cell adhesion signaling.

1. Pattern formation during T-cell adhesion.

Review 2. Central role of paxillin phosphorylation in regulation of LFA-1 integrins activity and lymphocyte migration.

3. Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses.

4. Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion.

5. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

Review 6. Dynamics of dendritic cell-T cell interactions: a role in T cell outcome.

Review 7. Chemokine control of lymphocyte trafficking: a general overview.

8. T-cell activation: A queuing theory analysis at low agonist density.

9. SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells.

Review 10. Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions.