Literature DB >> 15052257

A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism.

C Arlinde1, W Sommer, K Björk, M Reimers, P Hyytiä, K Kiianmaa, M Heilig.   

Abstract

Analyzing gene expression patterns in genetic models of alcoholism may uncover previously unknown susceptibility genes, and point to novel targets for drug development. Here, we compared expression profiles in alcohol-preferring AA rats with the alcohol-avoiding counterpart ANA line, and unselected Wistar rats. Cingulate cortex, Nc. accumbens, amygdala and hippocampus of each line were analyzed using the Afymetrix RN U34 arrays and dChip 1.1 software. Analysis of line-specific expression revealed 48 differentially expressed genes between AA and ANA rats. Elevated hippocampal neuropeptide Y (NPY) was found in ANA rats in agreement with previous studies. A cluster of MAP-kinases indicating altered signal transduction was upregulated within the Nc. Accumbens of the AA line, and is of particular functional interest. Within the amygdala, a more loosely inter-related cluster of cytoskeleton-associated genes may point to structural abnormalities. The observed dysregulations may contribute to the alcohol-preferring phenotype.

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Year:  2004        PMID： 15052257     DOI： 10.1038/sj.tpj.6500243

Source DB:  PubMed          Journal:  Pharmacogenomics J        ISSN： 1470-269X            Impact factor:   3.550


  23 in total

1.  Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.

Authors:  Yue Wu; Erin L Lousberg; Lachlan M Moldenhauer; John D Hayball; Janet K Coller; Kenner C Rice; Linda R Watkins; Andrew A Somogyi; Mark R Hutchinson
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

2.  Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence.

Authors:  J D Tapocik; M Solomon; M Flanigan; M Meinhardt; E Barbier; J R Schank; M Schwandt; W H Sommer; M Heilig
Journal:  Pharmacogenomics J       Date:  2012-05-22       Impact factor: 3.550

3.  Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice.

Authors:  Roberto I Melendez; Jacqueline F McGinty; Peter W Kalivas; Howard C Becker
Journal:  Addict Biol       Date:  2011-08-04       Impact factor: 4.280

Review 4.  Genetic factors influencing alcohol dependence.

Authors:  R D Mayfield; R A Harris; M A Schuckit
Journal:  Br J Pharmacol       Date:  2008-03-24       Impact factor: 8.739

5.  Expression Profiling in Alcoholism Research.

Authors:  Susan E Bergeson; Ari E Berman; Peter R Dodd; Howard J Edenberg; Robert J Hitzemann; Joanne M Lewohl; Kerrie H Lodowski; Wolfgang H Sommer
Journal:  Alcohol Clin Exp Res       Date:  2005-06-01       Impact factor: 3.455

Review 6.  Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.

Authors:  Roberto Ciccocioppo; Daina Economidou; Andrea Cippitelli; Marino Cucculelli; Massimo Ubaldi; Laura Soverchia; Anbarasu Lourdusamy; Maurizio Massi
Journal:  Addict Biol       Date:  2006-09       Impact factor: 4.280

Review 7.  Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.

Authors:  Giorgio Gorini; Richard L Bell; R Dayne Mayfield
Journal:  Prog Mol Biol Transl Sci       Date:  2011       Impact factor: 3.622

8.  Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption.

Authors:  William J McBride; Mark W Kimpel; Jeanette N McClintick; Zheng-Ming Ding; Petri Hyytia; Giancarlo Colombo; Tiebing Liang; Howard J Edenberg; Lawrence Lumeng; Richard L Bell
Journal:  Alcohol       Date:  2013-10-01       Impact factor: 2.405

9.  Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats.

Authors:  Tiebing Liang; Mark W Kimpel; Jeanette N McClintick; Ashley R Skillman; Kevin McCall; Howard J Edenberg; Lucinda G Carr
Journal:  Genome Biol       Date:  2010-02-03       Impact factor: 13.583

10.  β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol.

Authors:  Karl Björk; Valeria Tronci; Annika Thorsell; Gianluigi Tanda; Natalie Hirth; Markus Heilig; Anita C Hansson; Wolfgang H Sommer
Journal:  Psychopharmacology (Berl)       Date:  2013-06-19       Impact factor: 4.530
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