| Literature DB >> 15051496 |
Vidhya V Iyer1, Tejas B Kadakia, Laura R McCabe, Richard C Schwartz.
Abstract
CCAAT/enhancer binding protein beta (C/EBPbeta) is known to play an important role in the expression of several genes necessary for bone development and homeostasis including osteocalcin, IGF-1, and IL-6. In this study, we show that C/EBPbeta protein levels and, consequently, DNA-binding activity are temporally regulated, dramatically decreasing upon differentiation of MC3T3-E1 mouse osteoblasts. Corresponding with these results, the constitutive expression of C/EBPbeta LAP in MC3T3-E1 osteoblasts increased proliferation and suppressed osteogenic differentiation. Thus, C/EBPbeta LAP not only appears to participate in the regulation of genes associated with mature bone physiology, but is also a critical regulator of osteoblast growth and differentiation.Entities:
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Year: 2004 PMID： 15051496 DOI： 10.1016/j.yexcr.2004.01.004
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905