| Literature DB >> 15050708 |
Marton Graf1, Rita Jakus, Sandor Kantor, Gyorgy Levay, Gyorgy Bagdy.
Abstract
Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT7 receptors as well. Therefore, we have tested the effects of the selective 5-HT1A receptor antagonist WAY-100635 and the selective 5-HT7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike-wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT1A and 5-HT7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15050708 DOI： 10.1016/j.neulet.2004.01.072
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046