| Literature DB >> 15050642 |
Toshiyuki Kan1, Yusuke Tominari, Kentaro Rikimaru, Yuichi Morohashi, Hideaki Natsugari, Taisuke Tomita, Takeshi Iwatsubo, Tohru Fukuyama.
Abstract
Parallel synthesis of the C-terminal-modified DAPT (1) derivatives was accomplished utilizing our novel resin 7. Condensation reaction of the N-acylamino acid 10 with the amines 11a-o proceeded smoothly to give the corresponding amides 6a-o without any epimerization. Among the analogues, the benzophenonemethyl amide derivative 6o showed 30 times more potent activity than the original DAPT (1).Entities:
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Year: 2004 PMID： 15050642 DOI： 10.1016/j.bmcl.2004.01.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823