| Literature DB >> 15050630 |
Giancarlo Cravotto1, Gianni Balliano, Bruna Robaldo, Simonetta Oliaro-Bosso, Stefano Chimichi, Marco Boccalini.
Abstract
A few naturally occurring prenyl- and prenyloxycoumarins and several new related synthetic derivatives were evaluated as inhibitors of squalene-hopene cyclase (SHC), a useful model enzyme, to predict their interactions with oxidosqualene cyclase (OSC). Umbelliprenin-10',11'-monoepoxide (IC(50) 2.5 microM) and the corresponding 6',7'-10',11' diepoxide (IC(50) 1.5 microM) were the most active enzyme inhibitors.Entities:
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Year: 2004 PMID： 15050630 DOI： 10.1016/j.bmcl.2004.01.085
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823