| Literature DB >> 15050302 |
Alessandra Lugaresi1, Angelo Di Iorio, Carla Iarlori, Marcella Reale, Giovanna De Luca, Eleonora Sparvieri, Alessia Michetti, Pio Conti, Domenico Gambi, Giuseppe Abate, Roberto Paganelli.
Abstract
Cytokines appear to be involved in the pathogenesis of Alzheimer's Disease (AD). Their modulation by treatment has been investigated only in a few studies. The aim of our study was to evaluate the effect of acetylcholinesterase inhibitors (AChEI) on Interleukin-4 (IL-4) production in AD patients. IL-4 levels were measured by ELISA on peripheral blood mononuclear cell cultures in the presence or absence of Concanavalin A or Phytohaemagglutinin. Linear regression analysis shows that patients who have been treated, have higher levels of IL-4 independently from age, gender and comorbidity. The increased production of IL-4 in AChEI treated patients might represent an additional mechanism through which AChEI act on AD progression.Entities:
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Year: 2004 PMID： 15050302 DOI： 10.1016/j.exger.2003.08.012
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032