Literature DB >> 15048643

Possible epistatic role of ADH7 in the protection against alcoholism.

M V Osier1, R-B Lu, A J Pakstis, J R Kidd, S-Y Huang, Kenneth K Kidd.   

Abstract

In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD). Copyright 2003 Wiley-Liss, Inc.

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Year:  2004        PMID： 15048643     DOI： 10.1002/ajmg.b.20136

Source DB:  PubMed          Journal:  Am J Med Genet B Neuropsychiatr Genet        ISSN： 1552-4841            Impact factor:   3.568


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