Y Q Wu1, W G Zhang, Z Tian, Z Y Zhang. 1. School of Stomatology,Shanghai Second Medical University. Shanghai 200011, China.
Abstract
OBJECTIVE: The aim of this study was to investigate the expression of the E-cadherin-catenin(E-cad-cat) complex in human salivary adenoid cystic carcinoma(ACC) and determine the effects of E-cad-cat expression on tumor differentiation,metastasis and invasion as well as their clinical significance. METHODS: The expression of adhesion molecules,which included E-cadherin,alpha-catenin and beta-catenin,in 10 cases of normal salivary glands,50 cases of human salivary ACC was investigated by immunohistochemistry.RESULT:Co-expression of E-cadherin,alpha-catenin and beta-catenin was detected in 29(58%) of the 50 ACC specimens.Positive staining of E-cad-cat complex was detected in 7(39%) of the 18 ACC primary sites which had aggressive phenotype of nerve and vasculature. CONCLUSION: Strong positive signals of E-cad-cat complex were showed in normal salivary glands,and the down regulation expression was observed in ACC cases,The expression of E-cad-cat complex was associated with a more aggressive phenotype on nerve and vasculature.No association with various histopathologic subtypes was found;Down-regulation of E-cad-cat complex may be associated with canceration of normal salivary glands.
OBJECTIVE: The aim of this study was to investigate the expression of the E-cadherin-catenin(E-cad-cat) complex in humansalivary adenoid cystic carcinoma(ACC) and determine the effects of E-cad-cat expression on tumor differentiation,metastasis and invasion as well as their clinical significance. METHODS: The expression of adhesion molecules,which included E-cadherin,alpha-catenin and beta-catenin,in 10 cases of normal salivary glands,50 cases of human salivary ACC was investigated by immunohistochemistry.RESULT:Co-expression of E-cadherin,alpha-catenin and beta-catenin was detected in 29(58%) of the 50 ACC specimens.Positive staining of E-cad-cat complex was detected in 7(39%) of the 18 ACC primary sites which had aggressive phenotype of nerve and vasculature. CONCLUSION: Strong positive signals of E-cad-cat complex were showed in normal salivary glands,and the down regulation expression was observed in ACC cases,The expression of E-cad-cat complex was associated with a more aggressive phenotype on nerve and vasculature.No association with various histopathologic subtypes was found;Down-regulation of E-cad-cat complex may be associated with canceration of normal salivary glands.
Authors: Melkaye G Melka; Christina A Castellani; Nagalingam Rajakumar; Richard O'Reilly; Shiva M Singh Journal: BMC Neurosci Date: 2014-09-29 Impact factor: 3.288