| Literature DB >> 15048110 |
Fred S Harman1, Christopher J Nicol, Holly E Marin, Jerrold M Ward, Frank J Gonzalez, Jeffrey M Peters.
Abstract
Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.Entities:
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Year: 2004 PMID： 15048110 DOI： 10.1038/nm1026
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440