Literature DB >> 15047553

First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.

Jens Gieffers1, Jan Rupp, Andreas Gebert, Werner Solbach, Matthias Klinger.   

Abstract

Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.

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Year:  2004        PMID： 15047553      PMCID： PMC375316          DOI： 10.1128/AAC.48.4.1402-1405.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

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