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Literature DB >> 15047551

Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis.

Abstract

Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates (n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC(50)) of 0.12 microg/ml and a MIC(90) of 0.25 microg/ml. Staphylococcus epidermidis isolates (n = 96) were less susceptible, with a MIC(50) of 0.12 microg/ml and a MIC(90) of 8 microg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.

Entities: Chemical Species

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Year: 2004 PMID： 15047551 PMCID： PMC375325 DOI： 10.1128/AAC.48.4.1397-1399.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Guideline for Hand Hygiene in Health-Care Settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force.

Authors: John M Boyce; Didier Pittet
Journal: Infect Control Hosp Epidemiol Date: 2002-12 Impact factor: 3.254

2. Transferable resistance to triclosan in MRSA.

Authors: B D Cookson; H Farrelly; P Stapleton; R P Garvey; M R Price
Journal: Lancet Date: 1991-06-22 Impact factor: 79.321

3. Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.

Authors: R Chuanchuen; K Beinlich; T T Hoang; A Becher; R R Karkhoff-Schweizer; H P Schweizer
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

4. Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus.

Authors: C Slater-Radosti; G Van Aller; R Greenwood; R Nicholas; P M Keller; W E DeWolf; F Fan; D J Payne; D D Jaworski
Journal: J Antimicrob Chemother Date: 2001-07 Impact factor: 5.790

5. Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus.

Authors: Frank Fan; Kang Yan; Nicola G Wallis; Shannon Reed; Terrance D Moore; Stephen F Rittenhouse; Walter E DeWolf; Jianzhong Huang; Damien McDevitt; William H Miller; Mark A Seefeld; Kenneth A Newlander; Dalia R Jakas; Martha S Head; David J Payne
Journal: Antimicrob Agents Chemother Date: 2002-11 Impact factor: 5.191

6. Triclosan and antibiotic resistance in Staphylococcus aureus.

Authors: M T Suller; A D Russell
Journal: J Antimicrob Chemother Date: 2000-07 Impact factor: 5.790

7. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.

Authors: L M McMurry; P F McDermott; S B Levy
Journal: Antimicrob Agents Chemother Date: 1999-03 Impact factor: 5.191

Review 8. Literature-based evaluation of the potential risks associated with impregnation of medical devices and implants with triclosan.

Authors: Peter Gilbert; Andrew J McBain
Journal: Surg Infect (Larchmt) Date: 2002 Impact factor: 2.150

Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis.

1. Guideline for Hand Hygiene in Health-Care Settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force.

2. Transferable resistance to triclosan in MRSA.

3. Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.

4. Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus.

5. Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus.

6. Triclosan and antibiotic resistance in Staphylococcus aureus.

7. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.

Review 8. Literature-based evaluation of the potential risks associated with impregnation of medical devices and implants with triclosan.

9. The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.

10. Antibacterial household products: cause for concern.

1. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound.

2. Antibacterial cleaning products and drug resistance.

3. Antimicrobial biocides in the healthcare environment: efficacy, usage, policies, and perceived problems.

4. Staphylococcus epidermidis isolated in 1965 are more susceptible to triclosan than current isolates.