OBJECTIVES: Determination of the frequency and tissue distribution of inhibin-alpha (INH-alpha) in normal, hyperplastic and malignant endometrium. MATERIALS AND METHODS: Endometrial tissue was obtained from normal, hyperplastic (glandular-cystic hyperplasia), adenomatous hyperplasia (AH grade I to III) and endometroid adenocarcinoma and immunohistochemically characterized with INH-alpha antibody. RESULTS: INH-alpha was expressed in normal, hyperplastic and malignant endometrium. Highest expression was observed during secretory phase and glandular-cystic hyperplasia compared to all groups. A continuous decline was noted from AH grade I to III with a significance between AH I and II. DISCUSSION: A menstrual cycle associated expression of INH-alpha in glandular endometrial epithelium was observed. Since AH grade II and III can be considered as a precursor of endometrial cancer, INH-alpha could be a marker of cell transformation and an endometrial tumor-suppressor agent.
OBJECTIVES: Determination of the frequency and tissue distribution of inhibin-alpha (INH-alpha) in normal, hyperplastic and malignant endometrium. MATERIALS AND METHODS: Endometrial tissue was obtained from normal, hyperplastic (glandular-cystic hyperplasia), adenomatous hyperplasia (AH grade I to III) and endometroid adenocarcinoma and immunohistochemically characterized with INH-alpha antibody. RESULTS:INH-alpha was expressed in normal, hyperplastic and malignant endometrium. Highest expression was observed during secretory phase and glandular-cystic hyperplasia compared to all groups. A continuous decline was noted from AH grade I to III with a significance between AH I and II. DISCUSSION: A menstrual cycle associated expression of INH-alpha in glandular endometrial epithelium was observed. Since AH grade II and III can be considered as a precursor of endometrial cancer, INH-alpha could be a marker of cell transformation and an endometrial tumor-suppressor agent.
Authors: I Mylonas; B Schiessl; U Jeschke; J Vogl; A Makrigiannakis; C Kuhn; S Schulze; F Kainer; K Friese Journal: Endocr Pathol Date: 2006 Impact factor: 3.943
Authors: I Mylonas; B Schiessl; U Jeschke; J Vogl; A Makrigiannakis; C Kuhn; S Kunze; S Schulze; F Kainer; K Friese Journal: J Mol Histol Date: 2006-05-03 Impact factor: 2.611
Authors: Ioannis Mylonas; Udo Jeschke; Irmgard Wiest; Anna Hoeing; Julia Vogl; Naim Shabani; Christina Kuhn; Sandra Schulze; Markus S Kupka; Klaus Friese Journal: Histochem Cell Biol Date: 2004-10-12 Impact factor: 4.304