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Literature DB >> 15046607

Physiological functions of protein kinase B/Akt.

Z-Z Yang¹, O Tschopp, A Baudry, B Dümmler, D Hynx, B A Hemmings.

Abstract

The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals.

Entities: Gene Species

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Year: 2004 PMID： 15046607 DOI： 10.1042/bst0320350

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

90 in total

1. PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.

Authors: Qiuting Feng; Ruomin Di; Fang Tao; Zai Chang; Shuangshuang Lu; Wenjing Fan; Congjia Shan; Xinli Li; Zhongzhou Yang
Journal: Mol Cell Biol Date: 2010-05-10 Impact factor: 4.272

Review 2. Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.

Authors: Margrith E Mattmann; Sydney L Stoops; Craig W Lindsley
Journal: Expert Opin Ther Pat Date: 2011-06-02 Impact factor: 6.674

10. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.

Authors: Y Liao; Y Wei; X Zhou; J-Y Yang; C Dai; Y-J Chen; N K Agarwal; D Sarbassov; D Shi; D Yu; M-C Hung
Journal: Oncogene Date: 2009-05-18 Impact factor: 9.867

Physiological functions of protein kinase B/Akt.

1. PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.

Review 2. Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.

3. PKB/Akt partners with Dab2 in albumin endocytosis.

Review 4. Distinct biological roles for the akt family in mammary tumor progression.

5. Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.

6. A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

7. Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.

8. A purified capsular polysaccharide markedly inhibits inflammatory response during endotoxic shock.

9. InAKTivation of insulin/IGF-1 signaling by dephosphorylation.

10. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.