A modified temporal self-correlation method for analysis of fMRI time series.

Temporal self-correlation has recentlybeen proposed as a measure for fMRI-activation detection. In this paper, a modified temporal self-correlation method is introduced. The modified temporal self-correlation is based on the expectation value and standard deviation of the correlation coefficients between all pairs of epochs, while the original temporal self-correlation method is only based on the expectation value. Performance of the proposed method is evaluated on both simulated and in vivo fMRI data. Compared with the original temporal self-correlation method, the proposed method shows a significant improvement. In addition, a technique for quantitative comparison of different fMRI data analysis methods is proposed.