| Literature DB >> 15043132 |
Christopher McGuigan1, Antonella Carangio, Robert Snoeck, Graciela Andrei, Erik De Clercq, Jan Balzarini.
Abstract
The synthesis of 3'-fluoro analogues of recently discovered highly potent anti-VZV furanopyrimidine deoxynucleosides (BCNAs) is herein reported, for both the alkyl and alkylphenyl series. The compounds are tested against a range of herpes viruses and display poor activity, strongly supporting the notion of the importance of the presence of a 3'-OH for antiviral activity.Entities:
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Year: 2004 PMID： 15043132 DOI： 10.1081/ncn-120027813
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381