Literature DB >> 15042422

Effects of laser-modified versus osteopromotively coated titanium membranes on bone healing: a pilot study in rat mandibular defects.

H Deppe1, A Stemberger.   

Abstract

Regeneration of alveolar bone with membrane techniques has become an integral part of implant dentistry. The aim of the present study was to determine if laser-modified titanium membranes are of value in the regeneration of so-called critical size defects in the rat model compared with titanium membranes that were coated with growth factors. A total of 24 rats were included in the study. Critical size defects were created bilaterally and covered by titanium membranes coated with (1). polylactide, (2). polylactide and clindamycin, (3). polylactide and growth factors, (4). polylactide, clindamycin and growth factors and (5). uncoated but laser-modified titanium membranes. All 18 control defects were covered by titanium membranes without any substrate. Four weeks after treatment the animals were killed. Laser-modified titanium membranes (group 5) showed new bone formation in many areas. Nevertheless, complete bridging was found only in one specimen. In contrast, in groups 3 and 4, most defects showed almost complete bridging of the defects. In particular, clindamycin had no inhibitory effect on bone healing. Furthermore, after 28 days, there was no significant difference between the individual groups (including controls) with respect to the total amount of lamellar bone. Growth-factor-coated membranes can significantly accelerate the healing process of bony defects in the rat mandibular model. Nevertheless, it is not possible to accelerate bone healing with laser-irradiated membranes or to enhance the quality of bone within the time period examined.

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Year:  2004        PMID: 15042422     DOI: 10.1007/s10103-003-0279-1

Source DB:  PubMed          Journal:  Lasers Med Sci        ISSN: 0268-8921            Impact factor:   3.161


  13 in total

1.  Bone neogenesis in domes made of expanded polytetrafluoroethylene: efficacy of rhBMP-2 to enhance the amount of achievable bone in rats.

Authors:  G Zellin; A Linde
Journal:  Plast Reconstr Surg       Date:  1999-04       Impact factor: 4.730

2.  Characterization of sterilized CP titanium implant surfaces.

Authors:  J C Keller; R A Draughn; J P Wightman; W J Dougherty; S D Meletiou
Journal:  Int J Oral Maxillofac Implants       Date:  1990       Impact factor: 2.804

3.  Healing of bone defects by guided tissue regeneration.

Authors:  C Dahlin; A Linde; J Gottlow; S Nyman
Journal:  Plast Reconstr Surg       Date:  1988-05       Impact factor: 4.730

4.  Peri-implant care of ailing implants with the carbon dioxide laser.

Authors:  H Deppe; H H Horch; J Henke; K Donath
Journal:  Int J Oral Maxillofac Implants       Date:  2001 Sep-Oct       Impact factor: 2.804

5.  Conventional versus laser-assisted therapy of periimplantitis: a five-year comparative study.

Authors:  G Bach; C Neckel; C Mall; G Krekeler
Journal:  Implant Dent       Date:  2000       Impact factor: 2.454

6.  Alveolar ridge repair in a canine model using rhTGF-beta 1 with barrier membranes.

Authors:  J D Ruskin; R Hardwick; D Buser; C Dahlin; R K Schenk
Journal:  Clin Oral Implants Res       Date:  2000-04       Impact factor: 5.977

7.  Regeneration and enlargement of jaw bone using guided tissue regeneration.

Authors:  D Buser; U Brägger; N P Lang; S Nyman
Journal:  Clin Oral Implants Res       Date:  1990-12       Impact factor: 5.977

8.  Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-beta1) from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats.

Authors:  G Schmidmaier; B Wildemann; H Bail; M Lucke; T Fuchs; A Stemberger; A Flyvbjerg; N P Haas; M Raschke
Journal:  Bone       Date:  2001-04       Impact factor: 4.398

9.  Opposite effects of recombinant human transforming growth factor-beta 1 on bone regeneration in vivo: effects of exclusion of periosteal cells by microporous membrane.

Authors:  G Zellin; S Beck; R Hardwick; A Linde
Journal:  Bone       Date:  1998-06       Impact factor: 4.398

10.  Limited chondro-osteogenesis by recombinant human transforming growth factor-beta 1 in calvarial defects of adult baboons (Papio ursinus).

Authors:  U Ripamonti; C Bosch; B van den Heever; N Duneas; B Melsen; R Ebner
Journal:  J Bone Miner Res       Date:  1996-07       Impact factor: 6.741

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  1 in total

1.  Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats.

Authors:  Xiaorui Guo; Huiying Lu; Chunxiang Liu; Yi Zhang; Liangjia Bi
Journal:  Drug Des Devel Ther       Date:  2022-07-13       Impact factor: 4.319

  1 in total

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