OBJECTIVE: To analyse the association of alcohol consumption and blood lipids, haemostatic factors, and homocysteine in German adults by gender and age groups. DESIGN: Cross-sectional population-based survey. SETTING: Data from the German National Health Interview and Examination Survey 1998, representative for age, gender, community size, and federal state. SUBJECTS: From a sample of 7124 Germans between 18 and 79 y old, 2420 women and 2365 men were selected. Only individuals who were not currently receiving medical treatment or did not have disorders related to cardiovascular disease were selected for this study. RESULTS: Using analyses of variance, mean blood levels of total cholesterol, HDL cholesterol, HDL/total cholesterol ratio, total glycerides, fibrinogen, antithrombin III, and homocysteine adjusted for age, socioeconomic status, East/West Germany residence, body mass index, tobacco use, sports activity, and coffee consumption, if appropriate are presented by alcohol consumption groups (0, >0-10, >10-20, >20-30 and >30 g/day). The HDL/total cholesterol ratio increased with higher alcohol groups up to 10-20 g/day (+15%) for women and >30 g/day (+18%) for men, showing the strongest rise among men aged 55-79 y. Fibrinogen decreased with higher alcohol groups up to 10-20 g/day for women and 20-30 g/day for men. Among women, homocysteine levels showed a U-shaped curve with a minimum of 8.49 mmol/l at 10-20 g alcohol/day (-8%, reference: nondrinking), whereas an inverse association was observed for men. CONCLUSIONS: Moderate alcohol consumption is associated with favourable levels of several cardiovascular risk factors. The most favourable cardiovascular risk factor profile among women was observed among those drinking 10-20 g alcohol/day. Beneficial effects seem to be more pronounced among older men.
OBJECTIVE: To analyse the association of alcohol consumption and blood lipids, haemostatic factors, and homocysteine in German adults by gender and age groups. DESIGN: Cross-sectional population-based survey. SETTING: Data from the German National Health Interview and Examination Survey 1998, representative for age, gender, community size, and federal state. SUBJECTS: From a sample of 7124 Germans between 18 and 79 y old, 2420 women and 2365 men were selected. Only individuals who were not currently receiving medical treatment or did not have disorders related to cardiovascular disease were selected for this study. RESULTS: Using analyses of variance, mean blood levels of total cholesterol, HDL cholesterol, HDL/total cholesterol ratio, total glycerides, fibrinogen, antithrombin III, and homocysteine adjusted for age, socioeconomic status, East/West Germany residence, body mass index, tobacco use, sports activity, and coffee consumption, if appropriate are presented by alcohol consumption groups (0, >0-10, >10-20, >20-30 and >30 g/day). The HDL/total cholesterol ratio increased with higher alcohol groups up to 10-20 g/day (+15%) for women and >30 g/day (+18%) for men, showing the strongest rise among men aged 55-79 y. Fibrinogen decreased with higher alcohol groups up to 10-20 g/day for women and 20-30 g/day for men. Among women, homocysteine levels showed a U-shaped curve with a minimum of 8.49 mmol/l at 10-20 g alcohol/day (-8%, reference: nondrinking), whereas an inverse association was observed for men. CONCLUSIONS: Moderate alcohol consumption is associated with favourable levels of several cardiovascular risk factors. The most favourable cardiovascular risk factor profile among women was observed among those drinking 10-20 g alcohol/day. Beneficial effects seem to be more pronounced among older men.
Authors: Christopher W Kahler; David R Strong; George D Papandonatos; Suzanne M Colby; Melissa A Clark; Julie Boergers; Raymond Niaura; David B Abrams; Stephen L Buka Journal: Drug Alcohol Depend Date: 2007-10-25 Impact factor: 4.492
Authors: A Gibson; J V Woodside; I S Young; P C Sharpe; C Mercer; C C Patterson; M C McKinley; L A J Kluijtmans; A S Whitehead; A Evans Journal: QJM Date: 2008-09-12
Authors: Jens Baumert; Jie Huang; Barbara McKnight; Maria Sabater-Lleal; Maristella Steri; Audrey Y Chu; Stella Trompet; Lorna M Lopez; Myriam Fornage; Alexander Teumer; Weihong Tang; Alicja R Rudnicka; Anders Mälarstig; Jouke-Jan Hottenga; Maryam Kavousi; Jari Lahti; Toshiko Tanaka; Caroline Hayward; Jennifer E Huffman; Pierre-Emmanuel Morange; Lynda M Rose; Saonli Basu; Ann Rumley; David J Stott; Brendan M Buckley; Anton J M de Craen; Serena Sanna; Marco Masala; Reiner Biffar; Georg Homuth; Angela Silveira; Bengt Sennblad; Anuj Goel; Hugh Watkins; Martina Müller-Nurasyid; Regina Rückerl; Kent Taylor; Ming-Huei Chen; Eco J C de Geus; Albert Hofman; Jacqueline C M Witteman; Moniek P M de Maat; Aarno Palotie; Gail Davies; David S Siscovick; Ivana Kolcic; Sarah H Wild; Jaejoon Song; Wendy L McArdle; Ian Ford; Naveed Sattar; David Schlessinger; Anne Grotevendt; Maria Grazia Franzosi; Thomas Illig; Melanie Waldenberger; Thomas Lumley; Geoffrey H Tofler; Gonneke Willemsen; André G Uitterlinden; Fernando Rivadeneira; Katri Räikkönen; Daniel I Chasman; Aaron R Folsom; Gordon D Lowe; Rudi G J Westendorp; P Eline Slagboom; Francesco Cucca; Henri Wallaschofski; Rona J Strawbridge; Udo Seedorf; Wolfgang Koenig; Joshua C Bis; Kenneth J Mukamal; Jenny van Dongen; Elisabeth Widen; Oscar H Franco; John M Starr; Kiang Liu; Luigi Ferrucci; Ozren Polasek; James F Wilson; Tiphaine Oudot-Mellakh; Harry Campbell; Pau Navarro; Stefania Bandinelli; Johan Eriksson; Dorret I Boomsma; Abbas Dehghan; Robert Clarke; Anders Hamsten; Eric Boerwinkle; J Wouter Jukema; Silvia Naitza; Paul M Ridker; Henry Völzke; Ian J Deary; Alexander P Reiner; David-Alexandre Trégouët; Christopher J O'Donnell; David P Strachan; Annette Peters; Nicholas L Smith Journal: PLoS One Date: 2014-12-31 Impact factor: 3.240
Authors: Maria Patrizia Carrieri; Camelia Protopopescu; Vincent Le Moing; Philippe Reboud; François Raffi; Sophie Mahy; Perrine Roux; Lise Cuzin; Bruno Spire; Catherine Leport Journal: BMJ Open Date: 2012-11-23 Impact factor: 2.692