Literature DB >> 15040583

p47 GTPases: regulators of immunity to intracellular pathogens.

Gregory A Taylor1, Carl G Feng, Alan Sher.   

Abstract

Activation of the innate immune system by interferon-gamma (IFN-gamma is crucial for host resistance to infection. IFN-gamma induces the expression of a wide range of mediators that undermine the ability of pathogens to survive in host cells, including a newly discovered family of 47-kDa GTPases. Elimination of different p47 GTPases in mice by gene targeting severely cripples IFN-gamma-regulated defence against Toxoplasma gondii, Listeria monocytogenes, Mycobacterium spp. and other pathogens. In this article, we review our understanding of the role of p47 GTPases in resistance to intracellular infection and discuss the present evidence concerning their mode of action.

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Year:  2004        PMID： 15040583     DOI： 10.1038/nri1270

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  108 in total

1.  Microarray analysis of IFN-gamma response genes in astrocytes.

Authors:  Sandra K Halonen; Tyson Woods; Kate McInnerney; Louis M Weiss
Journal:  J Neuroimmunol       Date:  2006-04-21       Impact factor: 3.478

2.  The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

Authors:  Elisabeth Kravets; Daniel Degrandi; Stefanie Weidtkamp-Peters; Britta Ries; Carolin Konermann; Suren Felekyan; Julia M Dargazanli; Gerrit J K Praefcke; Claus A M Seidel; Lutz Schmitt; Sander H J Smits; Klaus Pfeffer
Journal:  J Biol Chem       Date:  2012-06-22       Impact factor: 5.157

3.  RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Authors:  Jun Ohshima; Miwa Sasai; Jianfa Liu; Kazuo Yamashita; Ji Su Ma; Youngae Lee; Hironori Bando; Jonathan C Howard; Shigeyuki Ebisu; Mikako Hayashi; Kiyoshi Takeda; Daron M Standley; Eva-Maria Frickel; Masahiro Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-03       Impact factor: 11.205

4.  p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.

Authors:  Barbara A Butcher; Robert I Greene; Stanley C Henry; Kimberly L Annecharico; J Brice Weinberg; Eric Y Denkers; Alan Sher; Gregory A Taylor
Journal:  Infect Immun       Date:  2005-06       Impact factor: 3.441

Review 5.  Subversion of innate and adaptive immune responses by Toxoplasma gondii.

Authors:  Christine Lang; Uwe Gross; Carsten G K Lüder
Journal:  Parasitol Res       Date:  2006-10-06       Impact factor: 2.289

6.  Hypoxia abrogates antichlamydial properties of IFN-γ in human fallopian tube cells in vitro and ex vivo.

Authors:  Anna Roth; Peter König; Ger van Zandbergen; Matthias Klinger; Thomas Hellwig-Bürgel; Walter Däubener; Michael K Bohlmann; Jan Rupp
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

7.  Balance of Irgm protein activities determines IFN-gamma-induced host defense.

Authors:  Stanley C Henry; Xiaoju G Daniell; Ashley R Burroughs; Maanasa Indaram; David N Howell; Jörn Coers; Michael N Starnbach; Julia P Hunn; Jonathan C Howard; Carl G Feng; Alan Sher; Gregory A Taylor
Journal:  J Leukoc Biol       Date:  2009-01-27       Impact factor: 4.962

8.  Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.

Authors:  Zhen Liu; Huifang M Zhang; Ji Yuan; Travis Lim; Alhousseynou Sall; Gregory A Taylor; Decheng Yang
Journal:  Cell Microbiol       Date:  2008-04-28       Impact factor: 3.715

9.  Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.

Authors:  Daniel Degrandi; Elisabeth Kravets; Carolin Konermann; Cornelia Beuter-Gunia; Verena Klümpers; Sarah Lahme; Eva Rasch; Anne K Mausberg; Sandra Beer-Hammer; Klaus Pfeffer
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205

10.  Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells.

Authors:  Hongwei Xu; Zhi-Ying Wu; Fang Fang; Lan Guo; Doris Chen; John Xi Chen; David Stern; Gregory A Taylor; Hong Jiang; Shirley ShiDu Yan
Journal:  FASEB J       Date:  2010-01-07       Impact factor: 5.191
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