| Literature DB >> 15039116 |
Ya-Qiu Jiang1, Hisayoshi Kawashima, Yasumasa Iwasaki, Katsuya Uchida, Koreaki Sugimoto, Keiichi Itoi.
Abstract
Corticotropin-releasing hormone (CRH) and vasopressin (AVP) colocalize in the parvocellular division of the paraventricular nucleus of the hypothalamus (PVN). We examined the effect of forced swim-stress on the CRH and AVP primary transcript (hnRNA) levels in the rat PVN by semi-quantitative in situ hybridization. CRH hnRNA increased markedly following 10-min swim-stress and returned to the basal level by 2 h. AVP hnRNA in the parvocellular division of the PVN, where AVP colocalizes with CRH, did not change significantly immediately after the swim-stress, but it did increase significantly 2 h after the stress. Pretreatment with dexamethasone abolished the increases in CRH and AVP hnRNA levels after the swim-stress. The present results demonstrate the differential effects of forced swim-stress on the CRH and AVP gene transcription in the parvocellular PVN, confirming the diverse response of the dual peptide-containing system in the face of acute stressful events.Entities:
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Year: 2004 PMID： 15039116 DOI： 10.1016/j.neulet.2004.01.041
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046