Literature DB >> 15037231

Strategies for dealing with metabolite elucidation in drug discovery and development.

Alaa-Eldin F Nassar1, Rasmy E Talaat.   

Abstract

Structural information on metabolites can be a considerable asset for enhancing and streamlining the process of developing new drug candidates. Modern approaches that generate and use metabolite structural information can accelerate the drug discovery and development process by eliminating potentially harmful candidates earlier in the process and improving the safety of new drugs. This review examines the relative merits of current and potential strategies for dealing with metabolite characterization.

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Year:  2004        PMID： 15037231     DOI： 10.1016/S1359-6446(03)03018-6

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  10 in total

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Journal:  Drug Discov Today       Date:  2016-12-02       Impact factor: 7.851

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7.  Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats.

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8.  Towards polypharmacokinetics: pharmacokinetics of multicomponent drugs and herbal medicines using a metabolomics approach.

Authors:  Ke Lan; Guoxiang Xie; Wei Jia
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-14       Impact factor: 2.629

9.  Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships.

Authors:  Mariusz Belka; Weronika Hewelt-Belka; Jarosław Sławiński; Tomasz Bączek
Journal:  PLoS One       Date:  2014-06-03       Impact factor: 3.240

Review 10.  Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health.

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Journal:  Front Microbiol       Date:  2016-07-26       Impact factor: 5.640
  10 in total

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