Literature DB >> 15036903

Recognition and function in a degenerate immune system.

Eli E Sercarz1, Emanual Maverakis.   

Abstract

Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.

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Year:  2004        PMID: 15036903     DOI: 10.1016/j.molimm.2003.11.002

Source DB:  PubMed          Journal:  Mol Immunol        ISSN: 0161-5890            Impact factor:   4.407


  6 in total

1.  Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice.

Authors:  Huiming Sheng; Saleema Hassanali; Courtney Nugent; Li Wen; Emma Hamilton-Williams; Peter Dias; Yang D Dai
Journal:  J Immunol       Date:  2011-07-06       Impact factor: 5.422

Review 2.  A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).

Authors:  Melvin Cohn
Journal:  Cell Mol Life Sci       Date:  2013-12-14       Impact factor: 9.261

Review 3.  T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.

Authors:  Jennifer D Stone; Adam S Chervin; David M Kranz
Journal:  Immunology       Date:  2009-02       Impact factor: 7.397

4.  Immunogenicity of GX301 cancer vaccine: Four (telomerase peptides) are better than one.

Authors:  Daniela Fenoglio; Alessia Parodi; Rosa Lavieri; Francesca Kalli; Francesca Ferrera; Augusto Tagliamacco; Andrea Guastalla; Maria Giuseppina Lamperti; Mauro Giacomini; Gilberto Filaci
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

5.  Pathophysiology of Autoimmune Bullous Diseases: Nature Versus Nurture.

Authors:  Forum Patel; Reason Wilken; Falin B Patel; Hawa Sultani; Itzel Bustos; Christopher Duong; John J Zone; Siba P Raychaudhuri; Emanual Maverakis
Journal:  Indian J Dermatol       Date:  2017 May-Jun       Impact factor: 1.494

Review 6.  Pre-existing heterologous T-cell immunity and neoantigen immunogenicity.

Authors:  Qibin Leng; Marion Tarbe; Qi Long; Feng Wang
Journal:  Clin Transl Immunology       Date:  2020-03-21
  6 in total

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