| Literature DB >> 15036654 |
Jung Hoon Yoon1, Youn Bae Kim, Myong Soo Kim, Joo Cheol Park, Joong Ki Kook, Hae Man Jung, Saeng Gon Kim, Hoon Yoo, Yeong Mu Ko, Sang Ho Lee, Bong Young Kim, Hong Sung Chun, Yoshikatsu Kanai, Hitoshi Endou, Do Kyung Kim.
Abstract
We have examined the expression and function of system l amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express l-type amino acid transporter 1 (LAT1) in plasma membrane, but not l-type amino acid transporter 2 (LAT2). The [14C]l-leucine uptake by KB cells is inhibited by system l selective inhibitor BCH. The majority of [14C]l-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.Entities:
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Year: 2004 PMID： 15036654 DOI： 10.1016/j.canlet.2003.10.009
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679