| Literature DB >> 15036585 |
Maria Concetta Geloso1, Valentina Corvino, Valentina Cavallo, Amelia Toesca, Enrico Guadagni, Roberto Passalacqua, Fabrizio Michetti.
Abstract
In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.Entities:
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Year: 2004 PMID： 15036585 DOI： 10.1016/j.neulet.2003.11.076
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046