OBJECTIVE: The effects on cortical rhythms of a single-dose (30 microg/kg) administration of the GABAA agonist lorazepam were examined in a randomized, double-blind, cross-over, placebo-controlled study with 8 healthy volunteers usingsimultaneous electroencephalography (EEG) and magnetoencephalography (MEG). METHODS: The oscillations were assessed by means of adaptive classification of short-term spectral patterns. RESULTS:Lorazepam (a) decreased the percentage of EEG/MEG segments with fast-theta, delta-alpha, fast-theta-alpha and alpha activity and increased percentage of EEG/MEG segments with delta, delta-slow-theta, delta-beta, slow-theta and polyrhythmic activity; (b) decreased diversity of EEG/MEG signals (in terms of spectral patterns) and increased the general instability of the signal; (c) increased stabilization periods of the spectral patterns (reduced brain information processing); (d) maintained larger maximum periods of temporal stabilization for delta, slow-theta, delta-slow-theta, delta-beta and polyrhythmic activity (in terms of spectral patterns); (e) did not increase power in the independent beta rhythm. CONCLUSIONS:Lorazepam caused significant reorganization of the EEG/MEG microstructure. These results suggest also that adaptive classification analysis of single short-term spectral patterns may provide additional information to conventional spectral analyses.
RCT Entities:
OBJECTIVE: The effects on cortical rhythms of a single-dose (30 microg/kg) administration of the GABAA agonist lorazepam were examined in a randomized, double-blind, cross-over, placebo-controlled study with 8 healthy volunteers using simultaneous electroencephalography (EEG) and magnetoencephalography (MEG). METHODS: The oscillations were assessed by means of adaptive classification of short-term spectral patterns. RESULTS:Lorazepam (a) decreased the percentage of EEG/MEG segments with fast-theta, delta-alpha, fast-theta-alpha and alpha activity and increased percentage of EEG/MEG segments with delta, delta-slow-theta, delta-beta, slow-theta and polyrhythmic activity; (b) decreased diversity of EEG/MEG signals (in terms of spectral patterns) and increased the general instability of the signal; (c) increased stabilization periods of the spectral patterns (reduced brain information processing); (d) maintained larger maximum periods of temporal stabilization for delta, slow-theta, delta-slow-theta, delta-beta and polyrhythmic activity (in terms of spectral patterns); (e) did not increase power in the independent beta rhythm. CONCLUSIONS:Lorazepam caused significant reorganization of the EEG/MEG microstructure. These results suggest also that adaptive classification analysis of single short-term spectral patterns may provide additional information to conventional spectral analyses.
Authors: Jeroen Van Schependom; Diego Vidaurre; Lars Costers; Martin Sjøgård; Marie B D'hooghe; Miguel D'haeseleer; Vincent Wens; Xavier De Tiège; Serge Goldman; Mark Woolrich; Guy Nagels Journal: Hum Brain Mapp Date: 2019-07-30 Impact factor: 5.038
Authors: Robin F H Cash; Yoshihiro Noda; Reza Zomorrodi; Natasha Radhu; Faranak Farzan; Tarek K Rajji; Paul B Fitzgerald; Robert Chen; Zafiris J Daskalakis; Daniel M Blumberger Journal: Neuropsychopharmacology Date: 2016-07-27 Impact factor: 7.853
Authors: V K Kimiskidis; S Papagiannopoulos; D A Kazis; K Sotirakoglou; G Vasiliadis; F Zara; A Kazis; K R Mills Journal: Exp Brain Res Date: 2006-03-09 Impact factor: 1.972
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