S D Spandorfer1, A Neuer, H C Liu, Z Rosenwaks, S S Witkin. 1. The Center for Reproductive Medicine and Infertility, The New York Hospital/Cornell Medical Center, New York, New York 10021, USA. sdspando@pop.med.cornell.edu
Abstract
PURPOSE: To examine the roles of Interleukin-1 (IL-1) and IL-1 receptor antagonist (IL-1ra), in in vitro embryo development and subsequent pregnancy outcome. METHODS: Maternal serum utilized to supplement embryo growth in IVF cycles was analyzed for the presence of IL-1 cytokines. RESULTS: The maternal serum that was utilized to supplement the embryo media was found to have measurable amounts of IL-1beta and IL-1ra. CONCLUSIONS: Relative antagonism of the IL-1 system was positively associated with embryo development and pregnancy outcome.
PURPOSE: To examine the roles of Interleukin-1 (IL-1) and IL-1 receptor antagonist (IL-1ra), in in vitro embryo development and subsequent pregnancy outcome. METHODS: Maternal serum utilized to supplement embryo growth in IVF cycles was analyzed for the presence of IL-1 cytokines. RESULTS: The maternal serum that was utilized to supplement the embryo media was found to have measurable amounts of IL-1beta and IL-1ra. CONCLUSIONS: Relative antagonism of the IL-1 system was positively associated with embryo development and pregnancy outcome.
Authors: S D Spandorfer; A Neuer; H C Liu; L Bivis; R Clarke; L Veeck; S S Witkin; Z Rosenwaks Journal: Am J Reprod Immunol Date: 2000-01 Impact factor: 3.886
Authors: Jie Yu; Sarah L Berga; Wei Zou; Augustine Rajakumar; Mingfei Man; Neil Sidell; Robert N Taylor Journal: J Clin Endocrinol Metab Date: 2020-09-01 Impact factor: 6.134
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