BACKGROUND: Taxanes (eg, paclitaxel) are chemotherapeutic agents that have antiproliferative, antiangiogenic, and antiinflammatory properties. OBJECTIVE: We sought to explore the safety and efficacy of paclitaxel in individuals with severe psoriasis. METHODS: An open-label, prospective, phase II pilot study was conducted at the National Institutes of Health Clinical Center, a federal government medical research facility, in Bethesda, Maryland. Twelve patients with severe psoriasis, as defined by a baseline Psoriasis Area and Severity Index (PASI) score of >or= 20), were studied. Initially, patients received 6 intravenous infusions of micellar paclitaxel, 75 mg/m(2), at 4-week intervals (stage I). Later patients received 9 intravenous infusions of micellar paclitaxel at 2-week intervals (37.5 mg/m(2) for 3 doses followed by 50 mg/m(2) for six additional doses) (stage II). The primary end point was the percent change in the PASI from week 0 to week 24 in stage I and from week 0 to week 20 in stage II. RESULTS: In stage I, all 5 patients improved (mean = 59.7% decrease in PASI, median = 59.6%, range: 40.3%-79.2%). Four of the 7 patients completed stage II and all of these patients improved (mean = 45.9% decrease in PASI, median = 45.0%, range: 14.6%-79.1%). Micellar paclitaxel was well tolerated by most patients. CONCLUSIONS: Micellar paclitaxel demonstrates therapeutic activity in patients with severe psoriasis.
BACKGROUND:Taxanes (eg, paclitaxel) are chemotherapeutic agents that have antiproliferative, antiangiogenic, and antiinflammatory properties. OBJECTIVE: We sought to explore the safety and efficacy of paclitaxel in individuals with severe psoriasis. METHODS: An open-label, prospective, phase II pilot study was conducted at the National Institutes of Health Clinical Center, a federal government medical research facility, in Bethesda, Maryland. Twelve patients with severe psoriasis, as defined by a baseline Psoriasis Area and Severity Index (PASI) score of >or= 20), were studied. Initially, patients received 6 intravenous infusions of micellar paclitaxel, 75 mg/m(2), at 4-week intervals (stage I). Later patients received 9 intravenous infusions of micellar paclitaxel at 2-week intervals (37.5 mg/m(2) for 3 doses followed by 50 mg/m(2) for six additional doses) (stage II). The primary end point was the percent change in the PASI from week 0 to week 24 in stage I and from week 0 to week 20 in stage II. RESULTS: In stage I, all 5 patients improved (mean = 59.7% decrease in PASI, median = 59.6%, range: 40.3%-79.2%). Four of the 7 patients completed stage II and all of these patients improved (mean = 45.9% decrease in PASI, median = 45.0%, range: 14.6%-79.1%). Micellar paclitaxel was well tolerated by most patients. CONCLUSIONS: Micellar paclitaxel demonstrates therapeutic activity in patients with severe psoriasis.
Authors: Brian E Kilfoyle; Larisa Sheihet; Zheng Zhang; Marissa Laohoo; Joachim Kohn; Bozena B Michniak-Kohn Journal: J Control Release Date: 2012-06-23 Impact factor: 9.776
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Authors: Efstathios Vassiliadis; Claudia P Oliveira; Mario R Alvares-da-Silva; Chen Zhang; Flair J Carrilho; Jose T Stefano; Fabiola Rabelo; Leila Pereira; Camila R Kappel; Kim Henriksen; Sanne Skovgård Veidal; Ben Vainer; Kevin L Duffin; Claus Christiansen; Diana J Leeming; Morten Karsdal Journal: Am J Transl Res Date: 2012-10-10 Impact factor: 4.060
Authors: Carlo Ballatore; Edward Hyde; Robert F Deiches; Virginia M-Y Lee; John Q Trojanowski; Donna Huryn; Amos B Smith Journal: Bioorg Med Chem Lett Date: 2007-04-25 Impact factor: 2.823
Authors: Mario A Moscarello; Helena Lei; Fabrizio G Mastronardi; Shawn Winer; Hubert Tsui; Zhen Li; Cameron Ackerley; Li Zhang; Reinout Raijmakers; D Denise Wood Journal: Dis Model Mech Date: 2012-11-01 Impact factor: 5.758