| Literature DB >> 15034132 |
Abstract
The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.Entities:
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Year: 2004 PMID： 15034132 DOI： 10.1093/molbev/msh125
Source DB: PubMed Journal: Mol Biol Evol ISSN： 0737-4038 Impact factor: 16.240