Literature DB >> 15034006

Immunohistochemical and mRNA localization of the angiotensin II receptor subtype 2 (AT2) in follicular granulosa cells of the rat ovary.

Nicholas Obermüller1, Monika Gentili, Stefan Gauer, Norbert Gretz, Michael Weigel, Helmut Geiger, Nikolaus Gassler.   

Abstract

A local renin-angiotensin system (RAS), including specific angiotensin II receptor subtypes, is present in the rat ovary. Immunohistochemistry using a polyclonal antibody and mRNA in situ hybridization were performed on perfusion-fixed, paraffin-embedded ovaries obtained from untreated sexually mature, normally cycling rats. Immunofluorescent staining revealed an exclusive and distinct labeling of follicular granulosa cells showing a plaque-like expression pattern at the cell borders, being detectable in different stages of atretic degeneration. On adjacent sections the expression of the respective mRNA could be shown in granulosa cells of the same follicle. The AT2 receptor may be implicated in the ovarian atretic process by influencing follicular cell-cell communication.

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Year:  2004        PMID： 15034006     DOI： 10.1177/002215540405200413

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  12 in total

Review 1.  The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target.

Authors:  U Muscha Steckelings; Robert E Widdop; Edward D Sturrock; Lizelle Lubbe; Tahir Hussain; Elena Kaschina; Thomas Unger; Anders Hallberg; Robert M Carey; Colin Sumners
Journal:  Pharmacol Rev       Date:  2022-10       Impact factor: 18.923

Review 2.  Interaction of SARS-CoV-2 With RAS / ACE2 in the Female Reproductive System.

Authors:  Farideh Zafari Zangeneh
Journal:  J Family Reprod Health       Date:  2022-03

3.  Characterization of a local renin-angiotensin system in rat gingival tissue.

Authors:  C F Santos; A E Akashi; T J Dionísio; C R Sipert; D N Didier; A S Greene; S H P Oliveira; H J V Pereira; C Becari; E B Oliveira; M C O Salgado
Journal:  J Periodontol       Date:  2009-01       Impact factor: 6.993

4.  Effect of Continuous Administration of Enalapril Maleate on the Oocyte Quality and In Vitro Production of Parthenote Embryos in Nulliparous and Multiparous Goats Undergoing Serial Laparoscopic Ovum Pick-Up.

Authors:  Pamela A Bravo; Maria E Moreno; César C L Fernandes; Rafael Rossetto; Camila M Cavalcanti; Denilsa P Fernandes; Davide Rondina
Journal:  Animals (Basel)       Date:  2019-10-26       Impact factor: 2.752

Review 5.  Local Renin-Angiotensin system in the reproductive system.

Authors:  Daniel Herr; Inga Bekes; Christine Wulff
Journal:  Front Endocrinol (Lausanne)       Date:  2013-10-18       Impact factor: 5.555

6.  Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging.

Authors:  Ana I Rodriguez-Perez; Ana Borrajo; Carmen Diaz-Ruiz; Pablo Garrido-Gil; Jose L Labandeira-Garcia
Journal:  Oncotarget       Date:  2016-05-24

7.  Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration.

Authors:  Rita Valenzuela; Maria A Costa-Besada; Javier Iglesias-Gonzalez; Emma Perez-Costas; Begoña Villar-Cheda; Pablo Garrido-Gil; Miguel Melendez-Ferro; Ramon Soto-Otero; Jose L Lanciego; Daniel Henrion; Rafael Franco; Jose L Labandeira-Garcia
Journal:  Cell Death Dis       Date:  2016-10-20       Impact factor: 8.469

8.  Interaction between Angiotensin Type 1, Type 2, and Mas Receptors to Regulate Adult Neurogenesis in the Brain Ventricular-Subventricular Zone.

Authors:  Maria Garcia-Garrote; Ana Perez-Villalba; Pablo Garrido-Gil; German Belenguer; Juan A Parga; Francisco Perez-Sanchez; Jose Luis Labandeira-Garcia; Isabel Fariñas; Jannette Rodriguez-Pallares
Journal:  Cells       Date:  2019-11-30       Impact factor: 6.600

9.  Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration.

Authors:  Carmen Diaz-Ruiz; Ana I Rodriguez-Perez; Daniel Beiroa; Jannette Rodriguez-Pallares; Jose L Labandeira-Garcia
Journal:  Oncotarget       Date:  2015-09-29

10.  The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system.

Authors:  Begoña Villar-Cheda; Maria A Costa-Besada; Rita Valenzuela; Emma Perez-Costas; Miguel Melendez-Ferro; Jose L Labandeira-Garcia
Journal:  Cell Death Dis       Date:  2017-09-07       Impact factor: 8.469
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