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Literature DB >> 1503398

Dominant genes for colorectal cancer are not rare.

R S Houlston¹, A Collins, J Slack, N E Morton.

Abstract

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

Entities: Disease Species

Mesh：

Year: 1992 PMID： 1503398 DOI： 10.1111/j.1469-1809.1992.tb01136.x

Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670

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Cited

22 in total

1. Lower prevalence of Lynch syndrome in colorectal cancer patients in a Japanese hospital-based population.

Authors: Kensuke Kumamoto; Hideyuki Ishida; Okihide Suzuki; Yusuke Tajima; Noriyasu Chika; Koki Kuwabara; Keiichiro Ishibashi; Katsuharu Saito; Koji Nagata; Hidetaka Eguchi; Junichi Tamaru; Takeo Iwama
Journal: Surg Today Date: 2015-08-07 Impact factor: 2.549

2. A genome wide linkage analysis in Swedish families with hereditary non-familial adenomatous polyposis/non-hereditary non-polyposis colorectal cancer.

Authors: T Djureinovic; J Skoglund; J Vandrovcova; X-L Zhou; A Kalushkova; L Iselius; A Lindblom
Journal: Gut Date: 2005-09-08 Impact factor: 23.059

Review 3. Serrated pathway colorectal cancer in the population: genetic consideration.

Authors: Joanne Young; Mark Jenkins; Susan Parry; Bruce Young; Derek Nancarrow; Dallas English; Graham Giles; Jeremy Jass
Journal: Gut Date: 2007-06-12 Impact factor: 23.059

Review 4. Genetic susceptibility to non-polyposis colorectal cancer.

Authors: H T Lynch; A de la Chapelle
Journal: J Med Genet Date: 1999-11 Impact factor: 6.318

5. Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission.

Authors: W-M Wong; N Mandir; R A Goodlad; B C Y Wong; S B Garcia; S-K Lam; N A Wright
Journal: Gut Date: 2002-02 Impact factor: 23.059

6. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.

Authors: Susa Enholm; Tuija Hienonen; Anu Suomalainen; Lara Lipton; Ian Tomlinson; Vesa Kärjä; Matti Eskelinen; Jukka-Pekka Mecklin; Auli Karhu; Heikki J Järvinen; Lauri A Aaltonen
Journal: Am J Pathol Date: 2003-09 Impact factor: 4.307

Dominant genes for colorectal cancer are not rare.

1. Lower prevalence of Lynch syndrome in colorectal cancer patients in a Japanese hospital-based population.

2. A genome wide linkage analysis in Swedish families with hereditary non-familial adenomatous polyposis/non-hereditary non-polyposis colorectal cancer.

Review 3. Serrated pathway colorectal cancer in the population: genetic consideration.

Review 4. Genetic susceptibility to non-polyposis colorectal cancer.

5. Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission.

6. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.

7. Chemotherapy resistant ovarian cancer in carriers of an hMSH2 mutation?

8. Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome.

9. Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk.

10. High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers.